Ammonia → HCID 44545610, compound

HRID 390512Notes

Reaction equation

HRID 390512 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)#[CH:13].N>>[Cl:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 10821PhenylacetyleneHCID 866368495-Chloro-N-hydroxynicotinimidoyl chloride

Product 1

HCID 44545610HCID 44545610, compound

Procedure

The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 1-ethynyl-benzene (Aldrich, 31 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.52-7.66 (m, 3H), 7.78 (s, 1H), 7.85-7.98 (m, 2H), 8.45 (t, J=2.1 Hz, 1H), 8.80 (d, J=2.4 Hz, 1H), 9.09 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 257 (M+H)+, 259 (M+H)+.

Sources & evidence

ORD record
ord-faeb4f885dcd46928e8f1956d5c5c0e1
Source dataset
uspto-grants-2013_02
Patent number
US08383658B2

Reaction notes

Loading…