HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(5-Chloropyridin-3-yl)-5-(4-fluoro-3-methylphenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Ethynyl-1-fluoro-2-methylbenzene | HCID 16213797 | — |
| Reactant | 5-Chloro-N-hydroxynicotinimidoyl chloride | HCID 86636849 | — |
| Product | 3-(5-Chloropyridin-3-yl)-5-(4-fluoro-3-methylphenyl)isoxazole | HCID 44545612 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 69B (57 mg, 0.3 mmol) and 4-ethynyl-1-fluoro-2-methylbenzene (Aldrich, 40 mg, 0.3 mmol). 1H NMR (300 MHz, DMSO-d6) δ2.34 (d, J=2.0 Hz, 3H), 7.38 (t, J=9.2 Hz, 1H), 7.72 (s, 1H), 7.74-7.81 (m, 1H), 7.84-7.91 (m, 1H), 8.42 (t, J=2.1 Hz, 1H), 8.80 (d, J=2.4 Hz, 1H), 9.07 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 289 (M+H)+, 291 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-aabd6e9b5fae424daa6ed15c1771e622 |
| Source note | uspto-grants-2013_02 |