Ammonia → 3-(Pyrazin-2-yl)-5-(pyridin-3-yl)isoxazole

Participants

Reaction Steps

The titled compound was prepared as the bishydrochloride salt according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 3-ethynylpyridine (Aldrich, 0.52 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.77 (dd, J=7.9, 5.2 Hz, 1H), 7.92 (s, 1H), 8.55 (dt, J=7.9, 1.8 Hz, 2H), 8.76-8.98 (m, 3 H), 9.32 (d, J=1.2 Hz, 2H) ppm; MS (DCI/NH3) m/z 225 (M+H)+.

Provenance & Evidence