HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(Pyrazin-2-yl)-5-(3,4,5-trifluorophenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Ethynyl-1,2,3-trifluorobenzene | HCID 22709071 | — |
| Reactant | N-Hydroxypyrazine-2-carbimidoyl chloride | HCID 136395910 | — |
| Product | 3-(Pyrazin-2-yl)-5-(3,4,5-trifluorophenyl)isoxazole | HCID 44545684 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 5-ethynyl-1,2,3-trifluorobenzene (Apollo, 78 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.53 (s, 1H), 7.79 (dd, J=8.5, 6.4 Hz, 2H), 8.70 (d, J=2.4 Hz, 1H), 8.76 (dd, J=2.5, 1.5 Hz, 1H), 9.29 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 278 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-1f77d414c9fa4b21b4c6d2ed655598ec |
| Source note | uspto-grants-2013_02 |