HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(3-(3-(Pyrazin-2-yl)isoxazol-5-yl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-(3-Ethynylphenyl)ethanone | HCID 15181428 | — |
| Reactant | N-Hydroxypyrazine-2-carbimidoyl chloride | HCID 136395910 | — |
| Product | 1-(3-(3-(Pyrazin-2-yl)isoxazol-5-yl)phenyl)ethanone | HCID 44545685 | — |
Reaction Steps
The titled compound was prepared according to Method CB using the product of Example 83D (79 mg, 0.5 mmol) and 1-(3-ethynylphenyl)ethanone (GFS Chemicals, 72 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 2.70 (s, 3H), 7.55 (s, 1H), 7.71 (t, J=7.8 Hz, 1H), 8.07-8.23 (m, 2H), 8.52 (t, J=1.7 Hz, 1H), 8.70 (d, J=2.7 Hz, 1H), 8.74-8.82 (m, 1H), 9.31 (d, J=1.7 Hz, 1H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383658B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-986aa1f3e8964291b316241a4b3db6d0 |
| Source note | uspto-grants-2013_02 |