Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-(6-Chloropyridin-3-yl)-5-(2,4-difluorophenyl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 1-Ethynyl-2,4-difluorobenzene | HCID 5063820 | — |
| 반응물 | 6-Chloro-N-hydroxynicotinimidoyl chloride | HCID 76573125 | — |
| 생성물 | 3-(6-Chloropyridin-3-yl)-5-(2,4-difluorophenyl)isoxazole | HCID 44545686 | — |
반응 단계
The titled compound was prepared according to Method CB using the product of Example 95B (79 mg, 0.5 mmol) and 1-ethynyl-2,4-difluorobenzene (Aldrich, 68 mg, 0.5 mmol). 1H NMR (300 MHz, CDCl3) δ 6.93-7.14 (m, 3H), 7.47 (d, J=7.5 Hz, 1H), 8.02 (td, J=8.6, 6.3 Hz, 1H), 8.18 (dd, J=8.1, 2.7 Hz, 1H), 8.86 (dd, J=2.5, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 293 (M+H)+, 295 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-6cb2867052af4f6096c6de81cb47e6fd |
| 출처 메모 | uspto-grants-2013_02 |