Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(3-Chlorophenyl)-3-(6-chloropyridin-3-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 1-Chloro-3-ethynylbenzene | HCID 123086 | — |
| 반응물 | 6-Chloro-N-hydroxynicotinimidoyl chloride | HCID 76573125 | — |
| 생성물 | 5-(3-Chlorophenyl)-3-(6-chloropyridin-3-yl)isoxazole | HCID 44545687 | — |
반응 단계
The titled compound was prepared according to Method CB using the product of Example 95B (79 mg, 0.5 mmol) and 1-chloro-3-ethynylbenzene (Apollo, 68 mg, 0.5 mmol). 1H NMR (300 MHz, CDCl3) δ6.88 (s, 1H), 7.43-7.52 (m, 3H), 7.69-7.78 (m, 1H), 7.81-7.89 (m, 1H), 8.18 (dd, J=8.3, 2.4 Hz, 1H), 8.84 (d, J=2.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 291 (M+H)+, 293 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-2f02d6f46b2b4464ab8079d8b68987cd |
| 출처 메모 | uspto-grants-2013_02 |