関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | tert-Butyl chloroacetate | HCID 66052 | — |
| 反応物 | HCID 178506575 | HCID 178506575 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester | HCID 57978086 | — |
反応手順
A mixture of 3-iodo-7-azaindazole (25.50 g) and K2CO3 (41.4 g) in DMF (200 mL) was heated to 85° C. and t-butyl chloroacetate (14.3 mL) was slowly added. The mixture was stirred at this temperature for 1 hour (h), cooled to room temperature followed by the addition of water (300 mL). Filtration of the reaction mixture provided (3-iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08383630B2 |
|---|
| 出典データセット | uspto-grants-2013_02 |
|---|
| ORD ID | ord-d2b31d0b2c7c4fb280406fd107ad1bfa |
|---|
| 出典メモ | uspto-grants-2013_02 |
|---|
