n-Heptyl isocyanate → Ethyl 2-[1-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]meth-(e)-ylidene]butyrate

Participants

Reaction Conditions

Reaction Steps

172 μL (1 mmol) of heptyl isocyanate are added to 214 mg (0.7 mmol) of ethyl 2-[1-(3′-methylaminobiphenyl-4-yl)meth-(E)-ylidene]butyrate. The reaction mixture is heated at 100° C. in an Emrys Optimizer microwave oven for 20 minutes. The residue is purified by chromatography on a column of silica eluted with a 70/30 heptane/ethyl acetate mixture. 306 mg (98%) of ethyl 2-[1-[3′-(3-heptyl-1-methylureido)biphenyl-4-yl]meth-(E)-ylidene]butyrate are obtained in the form of yellowish crystals.

Provenance & Evidence