Diisopropylethylamine → HCID 86626082, compound

Participants

Reaction Steps

3.9 g (19.4 mmol) of 4-nitrophenyl chloroformate and then 3.4 mL (19.4 mmol) of diisopropylethylamine are added to a solution of 4.8 g (16.1 mmol) of methyl (Z)-2-methoxy-3-(3′-methylaminobiphenyl-4-yl)acrylate. The reaction medium is stirred at room temperature for 2 hours. The reaction medium is hydrolyzed and then extracted with dichloromethane. The organic phase is washed with water, dried over magnesium sulfate, filtered and evaporated. 7.4 g (100%) of methyl (Z)-2-methoxy-3-{3′-[methyl-(4-nitrophenoxycarbonyl)amino]biphenyl-4-yl}acrylate are obtained in the form of a tacky foam.

Provenance & Evidence