Butylamine → HCID 16224425, compound

HRID 390616Notes

Reaction equation

[CH3:1][O:2]/[C:3](=[CH:8]\[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N:21]([CH3:34])[C:22](OC3C=CC([N+]([O-])=O)=CC=3)=[O:23])[CH:16]=2)=[CH:11][CH:10]=1)/[C:4]([O:6][CH3:7])=[O:5].[CH2:35]([NH2:39])[CH2:36][CH2:37][CH3:38]>>[CH2:35]([NH:39][C:22](=[O:23])[N:21]([C:17]1[CH:16]=[C:15]([C:12]2[CH:11]=[CH:10][C:9](/[CH:8]=[C:3](\[O:2][CH3:1])/[C:4]([O:6][CH3:7])=[O:5])=[CH:14][CH:13]=2)[CH:20]=[CH:19][CH:18]=1)[CH3:34])[CH2:36][CH2:37][CH3:38]

Participants

Reactant 2

HCID 8007Butylamine

HCID 86626082HCID 86626082, compound

Product 1

HCID 16224425HCID 16224425, compoundYield 64%

Procedure

In a manner similar to that of Example 10d, starting with 1.7 g (3.2 mmol) of methyl (Z)-2-methoxy-3-{3′-[methyl-(4-nitrophenoxycarbonyl)amino]biphenyl-4-yl}acrylate and 0.4 mL (3.9 mL) of n-butylamine, 0.8 g (64%) of methyl (Z)-3-[3′-(3-butyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylate is obtained in the form of a white solid with a melting point of 89° C.

Sources & evidence

ORD record: ord-a6d412db9f394449aeedc5c41db37659
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08383652B2

Reaction notes

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