Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → tert-Butyl 3-bromobenzylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Bromobenzylamine hydrochloride | HCID 2724980 | — |
| 반응물 | Tert-butyldicarbonate | HCID 22064466 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-Butyl 3-bromobenzylcarbamate | HCID 11033439 | 102.9% |
반응 단계
A solution of 25 g (110 mmol) of 3-bromobenzylamine hydrochloride and 24.5 g (110 mmol) of tert-butyl dicarbonate in 250 mL of dichloromethane in the presence of 15.6 mL (110 mmol) of triethylamine is stirred at room temperature for 16 hours. The reaction medium is washed with water, the phases are separated by settling and the organic phase is dried over sodium sulfate. The solvent is evaporated off and 32.4 g (100%) of tert-butyl (3-bromobenzyl)carbamate are obtained in the form of crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383652B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-e4f9b643759e42af80358c77fd71f19e |
| 출처 메모 | uspto-grants-2013_02 |