Trifluoroacetic acid → HCID 86626087, compound

Participants

Reaction Steps

g (2.2 mmol) of ethyl (E)-3-{2-butoxy-3′-[(tert-butoxycarbonylmethylamino)methyl]biphenyl-4-yl}-2-methylacrylate in 10 mL of dichloromethane and 1.5 mL of trifluoroacetic acid are stirred at room temperature for 2 hours 30 minutes. The reaction medium is evaporated to dryness and purified by chromatography on a column of silica eluted with a 98/2 and then 95/5 mixture of ethyl acetate and methanol. 1.1 g (84%) of ethyl (E)-3-(2-butoxy-3′-methylaminomethylbiphenyl-4-yl)-2-methylacrylate trifluoroacetate are obtained in the form of an orange oil.

Provenance & Evidence