反应详情

The (4-iodo-3-propoxyphenyl)methanol is dissolved in 30 mL of dichloromethane and 3.9 g (45 mmol) of manganese oxide are added. The reaction medium is stirred for 12 hours at room temperature. After filtering off the solid through Celite, the filtrate is evaporated under vacuum. The residue obtained is purified by chromatography on a column of silica eluted with a 9/1 heptane/ethyl acetate mixture. 1.5 g (57% yield for the three steps a-c) of 4-iodo-3-propoxybenzaldehyde are obtained.

1. filtrationAfter filtering off the solid through Celite
2. customthe filtrate is evaporated under vacuum
3. customThe residue obtained
4. customis purified by chromatography on a column of silica
5. washeluted with a 9/1 heptane/ethyl acetate mixture