Sodium Hydroxide → HCID 16224816, compound

Participants

Reaction Conditions

Reaction Steps

297 mg (7.4 mmol) of sodium hydroxide are added to a solution of 357 mg (0.74 mmol) of ethyl (E)-3-[2-ethoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methylacrylate in 15 mL of ethanol. The reaction mixture is heated at 50° C. for 3 hours. After cooling, the medium is evaporated to dryness, taken up in water, acidified with 2 N hydrochloric acid solution and extracted with ethyl acetate. The organic phases are combined, washed with water, dried over magnesium sulfate and filtered. The solvent is evaporated off and the solid obtained is taken up in a mixture of ethyl ether and pentane, filtered and dried. 250 mg (75%) of (E)-3-[2-ethoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methylacrylic acid are obtained in the form of a white powder with a melting point of 123° C.

Provenance & Evidence