Hydrochloric Acid → HCID 68961731, compound

Participants

Reaction Conditions

Reaction Steps

1.2 g (55 mmol) of lithium borohydride are added to a solution of 5.93 g (18 mmol) of methyl 3-(2-ethoxyethoxy)-4-iodobenzoate in 30 mL of tetrahydrofuran. The reaction mixture is heated at 60° C. overnight and then hydrolyzed in ice-cold saturated ammonium chloride solution. The reaction medium is neutralized with concentrated hydrochloric acid and then extracted with ethyl acetate. The organic phases are washed with water and dried over sodium sulfate. The solvent is evaporated off and 5.43 g (99%) of [3-(2-ethoxyethoxy)-4-iodophenyl]methanol are obtained in the form of a colorless oil.

Provenance & Evidence