反应详情

温度

50 °C

A mixture of 1 g (3 mmol) of ethyl (Z)-2-ethoxy-3-(3′-methylaminobiphenyl-4-yl)acrylate (prepared according to Example 41b) and 0.8 mL (6 mmol) of 4-methylphenyl isocyanate is placed in a sealed tube and heated at 50° C. for 15 hours. The reaction medium is cooled and the residue obtained is purified by chromatography on a column of silica eluted with a 7/3 heptane/ethyl acetate mixture. 1.2 g (85%) of ethyl (Z)-2-ethoxy-3-[3′-(1-methyl-3-p-tolylureido)biphenyl-4-yl]acrylate are obtained in the form of a white paste.

1. customis placed in a sealed tube
2. temperatureThe reaction medium is cooled
3. customthe residue obtained
4. customis purified by chromatography on a column of silica
5. washeluted with a 7/3 heptane/ethyl acetate mixture