HRID390688

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCO/C(=C\c1ccc(-c2cccc(N(C)C(=O)Nc3ccc(C(F)(F)F)cc3)c2)cc1)C(=O)O$

HCID16224328

未命名化合物

结构：CCOC(=O)/C(=C/c1ccc(-c2cccc(N(C)C(=O)Nc3ccc(C(F)(F)F)cc3)c2)cc1)OCC

HCID86626120

未命名化合物

PRODUCTS

生成物

$结构：CCO/C(=C\C(=O)O)c1ccc(-c2cccc(N(C)C(=O)Nc3ccc(C(F)(F)F)cc3)c2)cc1$

HCID131730266

未命名化合物

PROCEDURE

实验过程

In a manner similar to that of Example 43e, starting with 1.5 g (3 mmol) of ethyl (Z)-2-ethoxy-3-{3′-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylate, g (%) of (Z)-2-ethoxy-3-{3′-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acid are obtained in the form of a tacky paste.

WORKUP

后处理

customare obtained in the form of a tacky paste

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3fb6f4a9fca4434d81cdc2599ee0bdba
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08383652B2
来源说明: uspto-grants-2013_02

反应 SMILES

[CH2:1]([O:3]/C(=C\C1C=CC(C2C=CC=C(N(C)C(NC3C=CC(C(F)(F)F)=CC=3)=O)C=2)=CC=1)/C(OCC)=O)[CH3:2].C(O/[C:41](=[CH:45]\[C:46]1[CH:51]=[CH:50][C:49]([C:52]2[CH:57]=[CH:56][CH:55]=[C:54]([N:58]([CH3:72])[C:59]([NH:61][C:62]3[CH:67]=[CH:66][C:65]([C:68]([F:71])([F:70])[F:69])=[CH:64][CH:63]=3)=[O:60])[CH:53]=2)=[CH:48][CH:47]=1)/[C:42]([OH:44])=[O:43])C>>[CH3:2][CH2:1][O:3]/[C:45](/[C:46]1[CH:51]=[CH:50][C:49]([C:52]2[CH:57]=[CH:56][CH:55]=[C:54]([N:58]([CH3:72])[C:59]([NH:61][C:62]3[CH:63]=[CH:64][C:65]([C:68]([F:70])([F:69])[F:71])=[CH:66][CH:67]=3)=[O:60])[CH:53]=2)=[CH:48][CH:47]=1)=[CH:41]\[C:42]([OH:44])=[O:43]