(z)-2-Ethoxy-3-{3'-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acid → b-(Z)-2-ethoxy-3-{3'-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acid

HRID 390688Notes

Reaction equation

HRID 390688 reaction equation
[CH2:1]([O:3]/C(=C\C1C=CC(C2C=CC=C(N(C)C(NC3C=CC(C(F)(F)F)=CC=3)=O)C=2)=CC=1)/C(OCC)=O)[CH3:2].C(O/[C:41](=[CH:45]\[C:46]1[CH:51]=[CH:50][C:49]([C:52]2[CH:57]=[CH:56][CH:55]=[C:54]([N:58]([CH3:72])[C:59]([NH:61][C:62]3[CH:67]=[CH:66][C:65]([C:68]([F:71])([F:70])[F:69])=[CH:64][CH:63]=3)=[O:60])[CH:53]=2)=[CH:48][CH:47]=1)/[C:42]([OH:44])=[O:43])C>>[CH3:2][CH2:1][O:3]/[C:45](/[C:46]1[CH:51]=[CH:50][C:49]([C:52]2[CH:57]=[CH:56][CH:55]=[C:54]([N:58]([CH3:72])[C:59]([NH:61][C:62]3[CH:63]=[CH:64][C:65]([C:68]([F:70])([F:69])[F:71])=[CH:66][CH:67]=3)=[O:60])[CH:53]=2)=[CH:48][CH:47]=1)=[CH:41]\[C:42]([OH:44])=[O:43]

Participants

3

Reactant 2

HCID 16224328(z)-2-Ethoxy-3-{3'-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acidHCID 86626120ethyl (Z)-2-ethoxy-3-{3'-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylate

Product 1

HCID 131730266b-(Z)-2-ethoxy-3-{3'-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acid

Procedure

In a manner similar to that of Example 43e, starting with 1.5 g (3 mmol) of ethyl (Z)-2-ethoxy-3-{3′-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylate, g (%) of (Z)-2-ethoxy-3-{3′-[1-methyl-3-(4-trifluoromethylphenyl)ureido]biphenyl-4-yl}acrylic acid are obtained in the form of a tacky paste.

Workup

  1. customare obtained in the form of a tacky paste

Sources & evidence

ORD record
ord-3fb6f4a9fca4434d81cdc2599ee0bdba
Source dataset
uspto-grants-2013_02
Patent number
US08383652B2

Reaction notes

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