Sodium Hydroxide → HCID 58966530, compound

Participants

Reaction Steps

To a solution of methyl 1-{1-[2-({[3,5-bis(trifluoromethyl)benzyl](2-methyl-2H-tetrazol-5-yl)amino}methyl]-4-(trifluoromethyl)phenyl]propyl}-4-fluoropiperidine-4-carboxylate (example 204) (0.23 g, 0.33 mMol) in methanol was added 1N sodium hydroxide (1.8 mL.) and the solution was microwaved for 30 minutes at 100° C. The reaction mixture was diluted with water and the pH was adjusted to 3 and was extracted with dichloromethane. The organic extract was dried, concentrated and purified by flash chromatography to afford the title compound (0.9 g., 40%), 1HNMR (400 MHz. CDCl3) δ 7.90 (t, 1H), 7.80 (s, 1H), 7.60 (m, 37.15 (m, 1H), 4.70 (dd, 4H), 4.6 (m, 2H), 4.40 m, 2H), 4.10 (s, 3H), 3.80 (m, 1H), 2.90 (m, 1H), 3.60 (m, 2H), 2.40(m, 2H), 2.15 (m, 1H), 2.10 (m, 2H), 1.9 (m, 1H), 0.5 (t, 3H). MS (ES+) Calc 670.55, Found 671.4 (M+1)

Provenance & Evidence