Phthalimide → 2-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)isoindoline-1,3-dione

참여 물질

역할	이름	HCID	투입량
반응물	Phthalimide	HCID 6809	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine	HCID 46180726	—
용매	Dimethylformamide	HCID 6228	—
생성물	2-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)isoindoline-1,3-dione	HCID 59593108	80.3%

반응 단계

To a solution of 6-(bromomethyl)-2-chloro-4-morpholinothieno[3,2-d]pyrimidine 30 (0.3 g, 0.9 mmol) in DMF (10 mL) was added K2CO3 (0.2 g, 1.3 mmol), and phthalimide (0.1 g, 0.9 mmol). The resulting solution stirred 20 h at room temperature. The reaction was concentrated in vacuo and diluted with water (10 mL). The heterogeneous mixture was filtered to afford 2-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)isoindoline-1,3-dione 31 (0.3 g, 75%). MS (Q1) 415 (M)+

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08383620B2
출처 데이터셋	uspto-grants-2013_02
ORD ID	ord-7c839adbe09e4f38800692cd9a9d09c5
출처 메모	uspto-grants-2013_02