5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 24947048, compound

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Reaction Steps

4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-sulfonic acid dimethylamide was reacted with 2-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine in General Procedure A. Purification on silica yielded 111. NMR (CDCl3): 2.50-2.54 (4H, m, CH2), 2.74 (6H, s, Me), 3.21-3.24 (4H, m, CH2), 3.75 (2 H, s, CH2), 3.78-3.82 (4H, m, CH2), 3.95-3.98 (4H, m, CH2), 4.58 (2H, br s, NH2), 6.50 (1 H, d, J 8.6, Ar), 7.17 (1H, s, Ar), 8.38 (1H, dd, J 8.6 and 1.8, Ar) and 9.12 (1H, d, J 1.8, Ar). MS: (ESI+): MH+=519.34.

Provenance & Evidence