(2,4-Dimethoxypyrimidin-5-yl)boronic acid → HCID 24947049, compound

Participants

Reaction Steps

4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-sulfonic acid dimethylamide (Example 28) was reacted with 2,4-dimethoxypyrimidine-5-boronic acid in General Procedure A. Purification on silica yielded 113. NMR (CDCl3): 2.50-2.53 (4H, m, CH2), 2.75 (6H, s, Me), 3.21-3.24 (4H, m, CH2), 3.68-3.71 (6H, m, CH2), 3.94-3.98 (4H, m, CH2), 4.01 (3H, s, Me), 4.04 (3H, s, Me), 7.20 (1H, s, Ar) and 8.87 (1H, s, Ar). MS: (ESI+): MH+=565.44

Provenance & Evidence