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HRID390871

反应详情

EQUATION

反应方程式

HRID 390871 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2cnc(N)nc2)OC1(C)C
HCID17750212

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

C10H16BN3O2

结构：CC(C)(C)OC(=O)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1
HCID57494058

未命名化合物

PRODUCTS

生成物

1
结构：Nc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCNCC4)cc3n2)cn1
HCID58234035

未命名化合物

PROCEDURE

实验过程

2-Chloro-6-((4-Boc-piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine (200 mg) was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine 7 following General Procedure A followed by Boc removal with 1N HCl in dioxane to generate 159 after reversed phase HPLC purification. MS (Q1) 413 (M)+.

WORKUP

后处理

  1. customfollowed by Boc removal with 1N HCl in dioxane
  2. customafter reversed phase HPLC purification