(Pyrimidin-5-yl)boronic acid → HCID 58234043, compound

Participants

Reaction Steps

2-Chloro-6-(4-methyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine was reacted with pyrimidine-5-boronic acid in General Procedure A. Purification on silica yielded 169. NMR (CDCl3): 2.30 (3H, s, Me), 2.48-2.64 (8H, m, CH2), 3.71 (2H, s, CH2), 3.88-3.93 (4H, m, CH2), 3.98-4.03 (4H, m, CH2), 7.15 (1H, s, Ar), 9.21 (1H, s, Ar) and 9.62 (2H, s, Ar). MS: (ESI+): MH+ 412.33

Provenance & Evidence