tert-butyl Methyl(3-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbaMate → N,3-dimethyl-5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidin-2-yl)pyridin-2-amine

関与物質

反応手順

Methyl-[3-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-carbamic acid tert-butyl ester was reacted with 2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine in General Procedure A. Purification on silica yielded 361. NMR: (CDCl3): 2.54-2.58 (4 H, m), 2.72 (3 H, s), 3.04-3.07 (3 H, m), 3.18-3.21 (4 H, m), 3.72 (2 H, s), 3.78-3.80 (4 H, m), 3.85-3.88 (4 H, m), 4.40 (1 H, s, NH), 7.031 (1 H, s, Ar), 8.16 (1 H, s, Ar) and 9.09 (1 H, s, Ar). MS: (ESI+): MH+=518.24

情報源と証拠