2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine → HCID 58233875, compound

Participants

Reaction Steps

2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine was reacted with 2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine in General Procedure A. Purification on silica yielded 362. NMR: (CDCl3): 2.58-2.60 (4 H, m), 2.73 (3 H, s, Me), 3.20-3.22 (4 H, m), 3.75 (2 H, s), 3.81-3.84 (4 H, m), 3.90-3.92 (4 H, m), 4.76 (2 H, s, NH2), 6.92 (1 H, s, Ar), 7.25 (1 H, d, J 8.3, Ar), 8.61 (1 H, d, J 8.3, Ar) and 9.51 (1 H, s, Ar). MS: (ESI+): MH+=505.14

Provenance & Evidence