2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine → HCID 58234047, compound

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Reaction Steps

2-Chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine was reacted with ethyl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-carbamic acid tert-butyl ester in General Procedure A. Purification on silica yielded 365. NMR: (CDCl3): 1.31 (3 H, t, J 7.2, Me), 2.65-2.68 (4 H, m), 2.82 (3 H, s, Me), 3.28-3.31 (4 H, m), 3.38-3.44 (2 H, m, CH2), 3.81 (2 H, s, CH2), 3.88-3.90 (4 H, m), 3.94-3.97 (4 H, m), 4.71-4.74 (1 H, m, NH), 6.45 (1 H, d, J 8.7, Ar), 7.12 (1 H, s, Ar), 8.46 (1 H, dd, J 8.7 and 2.3, Ar) and 9.19 (1 H, d, J 2.3, Ar). MS: (ESI+): MH+=518.22

Provenance & Evidence