反应详情

2,3-Dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine was reacted with 2-chloro-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine in General Procedure A. Purification on silica yielded 371. NMR: (CDCl3): (400 MHz, CDCl3): 2.40 (3 H, s, Me), 2.59 (3 H, s, Me), 2.63-2.68 (4 H, m), 2.82 (3 H, s, Me), 3.29-3.31 (4 H, m), 3.84 (2 H, s, CH2), 3.90-3.92 (4 H, m), 3.98-4.00 (4 H, m), 7.17 (1 H, s, Ar), 8.41 (1 H, s, Ar) and 9.35 (1 H, s, Ar). MS: (ESI+): MH+ 503.15

1. customPurification on silica