HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Benzyl-N-methylpiperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | tert-Butyl 4-(benzyl(methyl)amino)piperidine-1-carboxylate | HCID 23292008 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Benzyl-N-methylpiperidin-4-amine | HCID 1096081 | — |
Reaction Steps
4-(Benzyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester was dissolved in DCM and methanol and 2.0M HCl in ether was added. After 3 hours the solvent was removed in vacuo and the residue was recrystallised from ethyl acetate/methanol to yield benzyl-methyl-piperidin-4-yl-amine (hydrochloride salt).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383620B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-4a116e8bac384aaca3af74ef5a9f4778 |
| Source note | uspto-grants-2013_02 |