反应详情

A solution of acetic acid 5-acetyl-indan-2-yl ester (Compound E-24; 1.50 g, 6.87 mmol) in dioxane (7 mL) was treated with 1.0 N sodium hydroxide (NaOH; 7.7 mL), and the solution was stirred at room temperature overnight. The solution was diluted with H2O (25 mL) and was extracted with CH2Cl2 (2×). The combined extracts were dried (MgSO4) and concentrated to give the title compound (1.06 g, 88%): 1H NMR δ 7.85 (s, 1H), 7.79 (m, 1H), 7.33 (d, J=7.7 Hz, 1H), 4.76 (m, 1H), 3.29-3.21 (m, 2H), 3.00-2.94 (m, 2H), 2.59 (s, 3H), 1.73 (d, J=5.3 Hz, 1H); ELMS m/z 176 (M+, 76), 161 (100).

1. extractionwas extracted with CH2Cl2 (2×)
2. dry with materialThe combined extracts were dried (MgSO4)
3. concentrationconcentrated