HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 391168Generated: October 25, 2026
Hexachloroacetone → 7alpha-Chloro-5,6beta-epoxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one
https://huagongshe.com/reaction/391168
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hexachloroacetone | HCID 8303 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5,6beta-Epoxy-7beta-hydroxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one | HCID 13075958 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7alpha-Chloro-5,6beta-epoxy-15beta,16beta-methylen-3beta-pivaloyloxy-5beta-androstan-17-one | HCID 13075960 | — |
Reaction Steps
reaction of compound 2 with hexachloroacetone in dichloromethane added with triphenylphosphine at a temperature of 0-5° C. followed by heating to 10-15° C., to yield 7α-chloro-5,6β-epoxy-15β,16β-methylen-3β-pivaloyloxy-5β-androstan-17-one 3:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08383809B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-226c6300fa36463398b09b01d9934d6c |
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| Source note | uspto-grants-2013_02 |
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