HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonate → (S)-2-Methyl-[1,4]bipiperidinyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonate | HCID 85570 | — |
| Reactant | BOC-(S)-2-Methyl-[1,4]bipiperidinyl | HCID 67423644 | — |
| Product | (S)-2-Methyl-[1,4]bipiperidinyl | HCID 28213026 | 94% |
Reaction Steps
The title compound was prepared in a manner substantially the same as intermediate (2S,31R)-2-Methyl-[1,3′]bipyrrolidinyl dihydrochloride by acid hydrolysis of BOC—(S)-2-Methyl-[1,4]bipiperidinyl which was synthesized by condensation of corresponding tosylate with (S)-(−)-2-methylpiperindine to get 1.37 g (94% yield) of the title product as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383814B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-c497a48b8897415ba28d5018287404bf |
| Source note | uspto-grants-2013_02 |