4-Aminoadamantan-1-ol → HCID 25242329, compound

HRID 391219Notes

Reaction equation

HRID 391219 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[NH2:19][CH:20]1[CH:27]2[CH2:28][C:23]3([OH:30])[CH2:24][CH:25]([CH2:29][CH:21]1[CH2:22]3)[CH2:26]2>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=2)[C:13]([NH:19][CH:20]2[CH:21]3[CH2:29][CH:25]4[CH2:24][C:23]([OH:30])([CH2:28][CH:27]2[CH2:26]4)[CH2:22]3)=[O:15])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 28574474-Aminoadamantan-1-olHCID 86651081HCID 86651081, compound

Product 1

HCID 25242329HCID 25242329, compound

Procedure

Prepared from 3-(6-chloro-pyridin-3-ylmethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ 8.49 (d, 1 H), 7.78 (dd, 1 H), 7.42-7.44 (m, 1 H), 7.38 (t, 2 H), 7.32 (d, 1 H), 7.10 (dd, 1 H), 6.32 (d, 1 H), 5.12 (s, 2 H), 4.19-4.24 (m, 1 H), 3.13 (br. s., 2 H), 2.26 (br. s., 2 H), 2.21 (br. s., 1 H), 1.95 (d, 2 H), 1.73-1.85 (m, 6 H), 1.59 (d, 2 H).

Sources & evidence

ORD record
ord-ba9a571d80404e28bb78dfb94546f153
Source dataset
uspto-grants-2013_02
Patent number
US08383820B2

Reaction notes

Loading…