4-Aminoadamantan-1-ol → HCID 25242291, compound

HRID 391229Notes

Reaction equation

HRID 391229 reaction equation
[CH2:1]([O:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=O)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:19][CH:20]1[CH:27]2[CH2:28][C:23]3([OH:30])[CH2:24][CH:25]([CH2:29][CH:21]1[CH2:22]3)[CH2:26]2>>[OH:30][C:23]12[CH2:28][CH:27]3[CH2:26][CH:25]([CH2:29][CH:21]([CH:20]3[NH:19][C:13](=[O:15])[C:12]3[CH:16]=[CH:17][CH:18]=[C:10]([O:9][CH2:1][CH2:2][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=4)[CH:11]=3)[CH2:22]1)[CH2:24]2

Participants

3

Reactant 2

HCID 28574474-Aminoadamantan-1-olHCID 159431683-(2-Phenylethoxy)benzoic acid

Product 1

HCID 25242291HCID 25242291, compound

Procedure

Prepared from 3-phenethyloxy-benzoic acid and 4-amino-1-hydroxyadamantane to give the title compound as a mixture of two isomers. 1H NMR (300 MHz, CDCl3): δ 7.20-7.39 (m, 8 H), 7.13 (dd, 0.3 H), 7.02 (dd, 0.7 H), 6.22-6.38 (m, 1 H), 4.09-4.28 (m, 3 H), 3.11 (t, 2 H), 2.24 (t, 2 H), 1.47-2.00 (m, 9 H).

Sources & evidence

ORD record
ord-40432fc89b5c478f8f52b314a794d0ad
Source dataset
uspto-grants-2013_02
Patent number
US08383820B2

Reaction notes

Loading…