反应详情

5-(3-Chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid (10 g) was suspended in toluene (50 ml) with stirring at room temperature, thionyl chloride (4.57 g) was added dropwise at 65-75° C., and the mixture was stirred for 1.5 hr. After cooling, the solvent was concentrated under reduced pressure, toluene (50 ml) was added to the residue, and the mixture was concentrated again under reduced pressure. The residue was dissolved in toluene (20 ml) to give a solution of 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoyl chloride in toluene. This was identified as the title compound by HPLC.

1. stirringthe mixture was stirred for 1.5 hr
2. temperatureAfter cooling
3. concentrationthe solvent was concentrated under reduced pressure, toluene (50 ml)
4. additionwas added to the residue
5. concentrationthe mixture was concentrated again under reduced pressure
6. dissolutionThe residue was dissolved in toluene (20 ml)