HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzenesulfonyl chloride → N-[5-(3-Chloro-4-cyano-phenyl)-pyridin-3-yl]-4-cyano-benzene-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzenesulfonyl chloride | HCID 39497 | — |
| Reactant | 4-(5-Amino-pyridin-3-yl)-2-chloro-benzonitrile | HCID 59578390 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[5-(3-Chloro-4-cyano-phenyl)-pyridin-3-yl]-4-cyano-benzene-sulfonamide | HCID 49819530 | — |
Reaction Steps
According to General Sulfonylation Procedure 2 in example 1, to a solution of 4-(5-amino-pyridin-3-yl)-2-chloro-benzonitrile (20 mg, 87 μmol, 1 eq) in anhydrous pyridine (500 μl) was added 4-cyano-benzenesulfonyl chloride (19.3 mg, 96 μmol, 1.1 eq).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383827B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-cb63c06ae0fa441b93a3bc4b30b9fb2a |
| Source note | uspto-grants-2013_02 |