反应详情

温度

50 °C

3,56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine and 2.24 parts of potassium t-butoxide were dissolved in 60 parts of n-butanol at room temperature then the solution was heated at 50° C. for 2 hours, with stirring. After this time, the solution was cooled and evaporated in vacuo. The residue was partitioned between ethyl acetate and water and the organic phase was separated and washed three times with water then dried (MgSO4). Evaporation of the solvent gave the crude product which was purified by chromatography on silica (Merck Kieselgel 60) eluted with ether to give 2-amino-4-n-butoxy-6-chloromethylpyrmidine as an oil.

1. temperatureAfter this time, the solution was cooled
2. customevaporated in vacuo
3. customThe residue was partitioned between ethyl acetate and water
4. customthe organic phase was separated
5. washwashed three times with water
6. dry with materialthen dried (MgSO4)
7. customEvaporation of the solvent
8. customgave the crude product which
9. customwas purified by chromatography on silica (Merck Kieselgel 60)
10. washeluted with ether