Ammonia → HCID 59578441, compound

HRID 391345Notes

Reaction equation

HRID 391345 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])[CH:11]=1.[NH3:21]>>[Cl:19][C:13]1[C:14]([Cl:18])=[CH:15][CH:16]=[CH:17][C:12]=1[C:10]1[CH:11]=[C:6]([CH2:5][CH2:4][C:3]([NH2:21])=[O:2])[CH:7]=[N:8][CH:9]=1

Participants

3

Reactant 2

HCID 222Ammonia2×HCID 595784053-[5-(2,3-Dichloro-phenyl)-pyridin-3-yl]-propionic acid methyl ester

Product 1

HCID 59578441HCID 59578441, compound

Procedure

A mixture of 3-[5-(2,3-dichloro-phenyl)-pyridin-3-yl]-propionic acid methyl ester and ammonia (7N in MeOH, 2 ml, 14.00 mmol) was stirred at room temperature for 24 hours. Ammonia (7N in MeOH, 1 ml, 7.00 mmol) was added, and the reaction mixture was stirred for another 24 hours. Solvent was removed in vacuo. The crude product was used in the next step without purification. ESI-MS m/z: 295 [M+1]+.

Workup

  1. stirringthe reaction mixture was stirred for another 24 hours
  2. customSolvent was removed in vacuo
  3. customThe crude product was used in the next step without purification

Sources & evidence

ORD record
ord-0545ad2e58cc4eab8729e1bc89cf3ac2
Source dataset
uspto-grants-2013_02
Patent number
US08383827B2

Reaction notes

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