Hydrochloric Acid → HCID 58993550, compound

Participants

Reaction Steps

tert-Butyl 4-((3-(1-methyl-1H-tetrazol-5-yl)-5-(trifluoromethyl)benzyloxy)methyl)-4-phenylpiperidine-1-carboxylate (7.0 mg, 0.01 mmol) was dissolved in a minimum amount of ethyl acetate, followed by addition of 4 N hydrochloric acid (0.5 mL). The mixture was stirred under nitrogen for 1 h. After removing the solvents, the crude mixture was precipitated in diethyl ether and filtered to afford 4.0 mg (88%). 1H-NMR (CDCl3, 500 MHz) δ 7.86 (s, 1H), 7.57 (s, 1H), 7.48 (s, 1H), 7.34 (s, 1H), 7.33 (s, 1H), 7.27-7.29 (m, 2H), 7.20 (m, 1H), 4.49 (s, 2H), 4.06 (s, 3H), 3.48 (s, 2H), 2.93-2.96 (m, 2H), 2.74-2.77 (m, 2H), 2.20-2.22 (m, 2H), 1.89-1.94 (m, 2H). Mass spec.: 432.20 (MH)+. Accurate mass spec.: m/z 432.1994 [MH]+, Δ=4.4 ppm.

Provenance & Evidence