HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Ethynylphenol → (S)-5-[(3-hydroxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Ethynylphenol | HCID 139144 | — |
| Reactant | (S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide | HCID 86629466 | — |
| Product | (S)-5-[(3-hydroxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24952780 | 17% |
Reaction Steps
In a manner similar to that describe in Example 425, a mixture of (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 3-hydroxy-1-ethynylbenzene were reacted to give the title compound as an off-white solid (19 mg, 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383825B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-a638a0c24f31478ba9daed426f94e777 |
| Source note | uspto-grants-2013_02 |