HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Iodosalicylic acid → (s)-2-Hydroxy-5-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Iodosalicylic acid | HCID 8388 | — |
| Reactant | (S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24953136 | — |
| Product | (s)-2-Hydroxy-5-{[5-({[methyl(oxo)phenyl-lambda6-sulfanylidene]amino}carbonyl)pyridin-3-yl]ethynyl}benzoic acid | HCID 24953844 | 45% |
Reaction Steps
In a manner similar to that describe in Example 434, a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 5-iodosalicyclic acid were reacted to give the title compound as a light tan solid (28 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383825B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-2ba09586f3944ac9adee28f74bc6abc9 |
| Source note | uspto-grants-2013_02 |