5-Iodo-2-methyl-1H-imidazole → (S)-5-[(2-methyl-1H-imidazol-5-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

HRID 391530Notes

Reaction equation

HRID 391530 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=1)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])#[CH:2].I[C:22]1[NH:26][C:25]([CH3:27])=[N:24][CH:23]=1>>[CH3:27][C:25]1[NH:24][C:23]([C:2]#[C:1][C:3]2[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=2)[C:8]([N:10]=[S@@:11]([CH3:19])(=[O:18])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:9])=[CH:22][N:26]=1

Participants

3

Reactant 2

HCID 27946235-Iodo-2-methyl-1H-imidazoleHCID 24953136(S)-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

Product 1

HCID 24954187(S)-5-[(2-methyl-1H-imidazol-5-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamideYield 51%

Procedure

In a manner similar to that describe in Example 434, a mixture of (S)-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 5-iodo-2-methyl-1H-imidazole were reacted to give the title compound as an off-white foam (28 mg, 51%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-e543e74bf9b94a93b9f0662362c154f2
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Reaction notes

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