HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromoisatin → (S)-5-[(2,3-dioxo-2,3-dihydro-1H-indol-5-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromoisatin | HCID 6889 | — |
| Reactant | (S)-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide | HCID 24953135 | — |
| Product | (S)-5-[(2,3-dioxo-2,3-dihydro-1H-indol-5-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24954550 | 22.2% |
Reaction Steps
In a manner similar to that described in Example 443, (S)—N-[methyl(oxo)phenyl-λ6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide (150 mg, 0.42 mmol) and 5-bromoisatin (116 mg, 0.46 mmol) were reacted to give the title compound as a reddish oil (40 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383825B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-7319453a349c46ae98f43266761c3258 |
| Source note | uspto-grants-2013_02 |