HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-iodopyridine → (S)-5-[(6-chloropyridin-3-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-iodopyridine | HCID 4397176 | — |
| Reactant | (S)-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide | HCID 24953135 | — |
| Product | (S)-5-[(6-chloropyridin-3-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24954920 | 90.2% |
Reaction Steps
In a manner similar to that described in Example 443, (S)—N-[methyl(oxo)phenyl-λ6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide (250 mg, 0.70 mmol) and 2-chloro-5-iodopyridine (173 mg, 0.70 mmol) were reacted to give the title compound as white solid (250 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383825B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-6f5932d038374fc38d75ddd6d73dfdbb |
| Source note | uspto-grants-2013_02 |