HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinamine, 5-iodo- → (S)-5-[(6-aminopyridin-3-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| Reactant | (S)-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide | HCID 24953135 | — |
| Product | (S)-5-[(6-aminopyridin-3-yl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide | HCID 24954921 | 84.4% |
Reaction Steps
In a manner similar to that described in Example 443, (S)—N-[methyl(oxo)phenyl-λ6-sulfanylidene]-5-[(trimethylsilyl)ethynyl]nicotinamide (100 mg, 0.28 mmol) and 2-amino-5-iodopyridine (69.3 mg, 0.31 mmol) were reacted to give the title compound as light yellow solid (89 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08383825B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d21dfc683b0741aea9b9179ab6072d33 |
| Source note | uspto-grants-2013_02 |