N-(4-Ethynylphenyl)-2,6-difluorobenzamide → HCID 24952782, compound

HRID 391540Notes

Reaction equation

HRID 391540 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:19])[C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[F:18])=[CH:5][CH:4]=1)#[CH:2].Br[C:21]1[CH:22]=[N:23][CH:24]=[C:25]([CH:38]=1)[C:26]([N:28]=[S@@:29]([CH3:37])(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27]>>[F:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([F:18])[C:11]=1[C:10]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[C:2][C:21]2[CH:22]=[N:23][CH:24]=[C:25]([CH:38]=2)[C:26]([N:28]=[S@@:29]([CH3:37])(=[O:36])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])=[CH:8][CH:7]=1)=[O:19]

Participants

3

Reactant 2

HCID 3785792N-(4-Ethynylphenyl)-2,6-difluorobenzamideHCID 86629466(S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide

Product 1

HCID 24952782HCID 24952782, compoundYield 74.3%

Procedure

In a manner similar to that described in Example 449, N-(4-ethynyl-phenyl)-2,6-difluoro-benzamide (0.114 g, 0.443 mmol) and (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide (100 mg, 0.295 mmol) were reacted to give the title compound as a solid (113 mg, 74%)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-47af3b9cdf6746c8885a502dc90015b0
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Reaction notes

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