HCID 16068636, compound → HCID 74318327, compound

HRID 391556Notes

Reaction equation

HRID 391556 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=1)[C:8]([N:10]=[S:11]([CH3:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])#[CH:2].Br[C:22]1[S:26][C:25]([NH:27][C:28](=[O:35])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[N:24][CH:23]=1>>[C:28]([NH:27][C:25]1[S:26][C:22]([C:2]#[C:1][C:3]2[CH:4]=[N:5][CH:6]=[C:7]([CH:20]=2)[C:8]([N:10]=[S:11]([CH3:19])(=[O:18])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:9])=[CH:23][N:24]=1)(=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 16068636HCID 16068636, compoundHCID 743721785-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

Product 1

HCID 74318327HCID 74318327, compoundYield 26.1%

Procedure

In a manner similar to that described in Example 462, 5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide (74 mg, 0.26 mmol), N-(5-bromo-1,3-thiazol-2-yl)benzamide (74 mg, 0.26 mmol) were reacted to give the title compound as a cream solid (33 mg, 26%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ba560f3751ba49958e48dd8366821fbd
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Reaction notes

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