5-Bromonicotinic acid → HCID 57657855, compound

HRID 391585Notes

Reaction equation

HRID 391585 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:7][CH:6]=1)(=[NH:4])=[O:3].[Br:19][C:20]1[CH:21]=[N:22][CH:23]=[C:24]([CH:28]=1)[C:25](O)=[O:26]>>[Br:19][C:20]1[CH:28]=[C:24]([C:25]([N:4]=[S:2]([C:5]2[CH:6]=[CH:7][C:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:17])[CH3:16])=[CH:9][CH:10]=2)([CH3:1])=[O:3])=[O:26])[CH:23]=[N:22][CH:21]=1

Participants

3

Reactant 2

HCID 887075-Bromonicotinic acidHCID 576578261027730-26-2

Product 1

HCID 57657855HCID 57657855, compoundYield 75%

Procedure

In a manner similar to that described in Example 480 (step 6), tert-Butyl [4-(S-methylsulfonimidoyl)phenyl]carbamate (0.141 g, 0.522 mmol) and 5-bromonicotinic acid (0.104 g, 0.522 mmol), were converted to the title compound (0.177 g, 75%).

Sources & evidence

ORD record
ord-91fb682484804722be440a1230250c9f
Source dataset
uspto-grants-2013_02
Patent number
US08383825B2

Reaction notes

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