HRID391586

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57657822

未命名化合物

结构：Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)O)c2)c1

HCID57657847

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1ccc(S(C)(=O)=NC(=O)c2cncc(C#Cc3cccc(NC(=O)c4occc4C)c3)c2)cc1

HCID24955631

未命名化合物

收率 94.6%

PROCEDURE

实验过程

In a manner similar to that described in Example 480 (step 6), Methyl 3-(4-(S-methylsulfonimidoyl)phenyl)propanoate (0.25 g, 1.037 mmol) and 5-((3-(3-methylfuran-2-carboxamido)phenyl)ethynyl)nicotinic acid (0.326 g, 0.943 mmol) reacted to give the title compound (0.508 g, 86%).

WORKUP

后处理

customreacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f05448a197c405cba731b74255216bd
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08383825B2
来源说明: uspto-grants-2013_02

反应 SMILES

[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:7][CH:6]=1)(=[NH:4])=[O:3].[CH3:17][C:18]1[CH:22]=[CH:21][O:20][C:19]=1[C:23]([NH:25][C:26]1[CH:27]=[C:28]([C:32]#[C:33][C:34]2[CH:35]=[N:36][CH:37]=[C:38]([CH:42]=2)[C:39](O)=[O:40])[CH:29]=[CH:30][CH:31]=1)=[O:24]>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[CH:9][CH:10]=1)(=[N:4][C:39]([C:38]1[CH:37]=[N:36][CH:35]=[C:34]([C:33]#[C:32][C:28]2[CH:29]=[CH:30][CH:31]=[C:26]([NH:25][C:23]([C:19]3[O:20][CH:21]=[CH:22][C:18]=3[CH3:17])=[O:24])[CH:27]=2)[CH:42]=1)=[O:40])=[O:3]