HRID391588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57657822

未命名化合物

结构：Cc1cc(C(=O)Nc2cccc(C#Cc3cc(C(=O)O)cnc3N)c2)n(C)n1

HCID57657867

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1ccc(S(C)(=O)=NC(=O)c2cnc(N)c(C#Cc3cccc(NC(=O)c4cc(C)nn4C)c3)c2)cc1

HCID24956709

未命名化合物

收率 42%

PROCEDURE

实验过程

In a manner similar to that described in Example 480 (step 6), 6-Amino-5-{3-[(2,5-dimethyl-2H-pyrazole-3-carbonyl)-amino]-phenylethynyl}-nicotinic acid (0.250 g, 0.666 mmol) and methyl 3-(4-(S-methylsulfonimidoyl)-phenyl)propanoate (0.160 g, 0.666 mmol) were reacted to give the title compound (0.167 g, 42%)

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-70ae11221e7e44bb9b4de20764a9904f
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08383825B2
来源说明: uspto-grants-2013_02

反应 SMILES

[NH2:1][C:2]1[C:10]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]3[N:23]([CH3:28])[N:24]=[C:25]([CH3:27])[CH:26]=3)=[O:21])[CH:14]=2)=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:29][S:30]([C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41]([O:43][CH3:44])=[O:42])=[CH:35][CH:34]=1)(=[NH:32])=[O:31]>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:32]=[S:30]([C:33]2[CH:34]=[CH:35][C:36]([CH2:39][CH2:40][C:41]([O:43][CH3:44])=[O:42])=[CH:37][CH:38]=2)([CH3:29])=[O:31])=[O:8])=[CH:9][C:10]=1[C:11]#[C:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20]([C:22]2[N:23]([CH3:28])[N:24]=[C:25]([CH3:27])[CH:26]=2)=[O:21])[CH:14]=1